Statin Treatment and 3′ Polyadenylation of eNOS mRNA
نویسندگان
چکیده
منابع مشابه
Statin treatment and 3' polyadenylation of eNOS mRNA.
OBJECTIVE Statins have been shown to increase endothelial nitric oxide synthase expression via enhanced mRNA stability. Because the poly(A) tail is an important determinant of transcript stability, we sought to characterize the effect of statins on eNOS mRNA 3' polyadenylation. METHODS AND RESULTS Endothelial cells treated with statins had a time- and dose-dependent increase in eNOS transcrip...
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The 3' poly(A) tail is important in messenger RNA stability and translational efficiency. In somatic tissues, 3' polyadenylation of mRNAs has been thought to largely be a constitutively active process. We have reported that laminar shear stress causes a brief increase in endothelial nitric oxide synthase (eNOS) transcription, followed by a prolonged increase in eNOS mRNA stability. We sought to...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2007
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.107.154492